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Etizolam vs. Xanax: What you should know

Which is better for anxiety- Etizolam or Clonazepam

Anxiety and panic attacks don’t just physically impact academic performance but even cause physical symptoms of digestive complications, chronic pain complications with overall poorer quality of life. Eventually, they force you to withdraw from social contact because of frequent signs of fear sensations without any external threat. In addition to marital stress and decline in relationship satisfaction, the anxiety symptoms impact your prospects with daily living.

Benzodiazepines are a popular treatment option for anxiety and enable you to lead an everyday life by conducting day-to-day activities freely. But misuse of these medications has been on the rise, with public health users unable to identify the exact statistics of abuse. Using data analytics, researchers have concluded that almost 12.5% of adults in The United States use benzodiazepines, of which 17.5% misuse them regularly.

Misused Benzodiazepines

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Etizolam and Xanax are two potent medications of the benzodiazepine family that are popular because of their anxiolytic properties. Etizolam is benzene with similar properties to that of benzodiazepines. Xanax is a derivative of Alprazolam medication and a triazolobenzodiazepine with similar therapeutic properties. It is essential to understand in detail either drug to have a better idea regarding their comparative analysis.

Etizolam in brief

Etizolam buy online UK was developed in Japan in the 1980s and soon became a potent anxiolytic globally. The use of Etizolam has been approved by Japan, Italy, India, and other countries but not by the United States, and it is regarded as a classified substance in Alabama, Arkansas, Florida, Georgia, Indiana, Louisiana, Ohio, Texas, South Carolina, Virginia, and Mississippi.

Etizolam UK buy is used in treating social anxiety with or without agoraphobia and is a practical option for generalized anxiety. In an open-label double-blind study conducted among 36 subjects diagnosed as suffering from Generalized Anxiety Disorder with associated depressive symptoms, Etizolam tablets produced favorable results in anxiety and depressive symptoms in comparison to placebo drugs. The somatic manifestations produced by Etizolam were particularly impressive in addition to safety and low tolerability.

In addition to anxiety, panic disorders with agoraphobia have even shown a favorable response to the use of Etizolam. The daytime drowsiness with associated side effects was of mild to moderate severity. Neurochemical research suggests that Etizolam may have selectivity for the subpopulation of Y-aminobutyric acid type A receptors associated with anxiety (i.e., α1, β2, γ2). This property, plus its characterization as a ligand with fewer adverse events typical of full agonists like impaired cognitive function, tolerance, and dependence, makes it a suitable option for patients with anxiety.

Gaba Receptor

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To date, there is no case of paradoxical reaction, i.e., an episode of inflammation with or without pus formation with significant deterioration in conditions of healing lesions. Etizolam has an anxiolytic action 6-8 times greater than Diazepam, while its single-dose pharmacokinetics and pharmacodynamics are influenced by polymorphic CYP2C19 activity. Off-label it is used as an added medication in the treatment of essential hypertension along with being used in cancer patients with anxiety.


Xanax is a derivative of the Alprazolam medication group and is a Schedule IV Controlled substance used to treat panic disorders and generalized anxiety. It is covered under the U.S patent and FDA-approved for treating generalized anxiety disorder with or without agoraphobia, i.e., fear of being in a place where it may be hard to leave. The Schedule I V nature of the drug makes it mandatory to obtain a prescription for it.

In addition to its FDA approval, Alprazolam, the active ingredient of Xanax, is recommended by the World Federation of Societies of Biological Psychiatry (WFSBP) for treatment-resistant cases of panic disorders without prior history of tolerance or dependence. Off-label, Xanax is used to treat nausea and vomiting in patients undergoing chemotherapy.

In addition to generalized anxiety disorder, Xanax has helped treat severe anxiety in patients undergoing alcohol withdrawal. Additionally, it has been beneficial in major depressive disorder conditions when prescribed double doses used for anxiety relief. Studies conducted to evaluate the effect of chronic Alprazolam intake on memory, attention, and psychomotor performance in healthy human male volunteers have found that chronic administration of Alprazolam affects memory but has no effects on attentive and psychomotor performance.

Xanax is metabolized by the CYP3A4 enzyme and works on the GABA receptors to bring out its anxiolytic properties. Its affinity to the  alpha-1 subunit mediates sedation, amnesia, and ataxic effects, and alpha-2 mediates anxiolytic and muscle-relaxing properties.

Gaba Pharmacology

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A comparison between Etizolam and Xanax

Etizolam reddit is a more potent anxiolytic than Xanax, with approximately ten times increased potency than Xanax or other alprazolam derivatives. Additionally, it is available in smaller strengths than Xanax, with doses of Etizolam being limited to 0.25mg, 0.5mg, 1mg, and 2mg, but doses of Xanax reach up to 3mg. But the effects of Etizolam last for a shorter time of 5-7 hours, while those of Xanax last longer for approximately 12 hours. Etizolam is not approved for use in the United States and has limited availability. Both medications have high rates of abuse that are risky for the users. Along with using them only under the physician’s guidance, care must be taken to use them judiciously.


  1. https://www.tandfonline.com/doi/abs/10.1185/03007999009111650
  2. https://www.sciencedirect.com/science/article/abs/pii/S014929180900472X
  3. https://pubmed.ncbi.nlm.nih.gov/1551746/
  4. https://en.wikipedia.org/wiki/Alprazolam

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