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Using Modafinil 200mg to Thrive in the UK’s Fast-Paced Environment

Using Modafinil 200mg to Thrive in the UK’s Fast-Paced Environment

Recent studies have shown that stress and anxiety levels are on the rise in the U.K. with students and younger aged people seemingly most impacted because of it. While academic pressure, time problems, work demands, and assorted problems were regarded as the chief stress-related factors, what further came into the limelight during the trials was the use of psychostimulants chiefly Modafinil used by students to cope with the pressure successfully.

Buy Modafinil 200 mg UK, is an FDA-approved eugeroic medication developed for treating narcolepsy, SWSD, and sleep apnea patients dealing with excessive daytime sleepiness and fatigue. But despite its prescription status, the medication is increasingly used in an off-label manner to increase cognitive performance and deal with anxiety, stress, and fatigue.

On a natural language processing-based analysis of patient experience posts conducted by researchers at the University of Warwick, U.K. It was recorded to be used for a total of 33 conditions other than its FDA-approved use of SWSD and narcolepsy.

Patients reported using it for depression, sleep-related breathing disorders, conditions of Multiple Sclerosis, and even general fatigue. Even people with cancer, traumatic brain injury, diabetes, fibromyalgia, general pain, autoimmune conditions, or overall multiple multiple morbidities with 2-4 concurrent conditions used to deal with fatigue or improve their cognitive functions.

NLP Analysis

Image Credit – Spontaneously Generated Online Patient Experience of Modafinil: A Qualitative and NLP Analysis

Depending on the intensity of the problem, the users further described the frequency with which they used Modafinil. The majority of the users reported overall satisfaction with using it and only a minor percentage discontinued using it because of side effects or adverse reactions.

Considering the growing incidence of depression since the pandemic with 17% of the population dealing with depression with a similar increase in pain incidence, the prospect of having a psychostimulant like Modafinil as a potential secondary treatment can be regarded as an assuring prospect for chronic impacted patients.

How Does Modafinil work on depression and pain?

Animal studies have shown that Modafinil works on the neurotoxin 5,7-dihydroxytryptamine is selective for serotonin neurons and thus plays an important role in managing depressive symptoms successfully. It was further observed to decrease cortical GABA through a serotonin-mediated pathway to manage anxiety symptoms successfully.

While it increases waking and labeling of Fos, a marker of neuronal activation, it does not directly impact GABA uptake, release, or glutamate decarboxylase activity. Rather it decreases GABA in the medial preoptic area of the hypothalamus and posterior hypothalamus. The preoptic area of the hypothalamus is crucial in sleep and temperature regulation while the posterior hypothalamus is involved in movement control, emotions, arousal, and memory processing that are impacted in patients with depression, chronic anxiety, and ADHD.

Even more crucial is the impact of Modafinil in the striatum, palladium, and substantia nigra that are directly involved in working memory and cognitive flexibility. The total of the research showed that it can improve motor activity and that in turn works in pain and fatigue management in cancer, multiple sclerosis, and fibromyalgia patients.

The fatigue management, memory enhancement, and motor control are a great help in healthy adults especially students in improving cognitive potential, increasing concentration, and overcoming sleepiness.

Modafinil use in the younger population 

It has been previously established that the use of it increases alertness and neurobehavioral function in addition to improving executive functions. However, what has caught the attention of researchers is the recent increase in the use of Modafinil in otherwise healthy individuals to improve their cognitive skills and cope with work/academics-related stress.

Studies conducted on off-prescription use of Modafinil by London South Bank University showed Modafinil to be the most commonly used medication, especially in students in the mean age of 27.

We have to understand that a lot of people are interested in neuroenhancement, an improvement in cognitive, emotional, and motivational functions with or without the use of psychostimulants like Modafinil. What sets apart Modafinil from other medications like Methylphenidate is its marked impact on the cortical centers of the brain regulating memory, attention, and wakefulness with a subsequent positive impact on academic capabilities.

An important aspect that marks the popularity of Modafinil is the almost negligible risk of addiction associated with its use in comparison to medications like Ritalin and Adderall which have a higher risk of addiction associated with their use.

Other than the cognitive impacts, an important aspect of Modafinil was that, unlike common psycho-stimulants like Caffeine, it produced very minimal after-effects and could be used for a prolonged period


Image Credit – The off-prescription use of modafinil: An online survey of perceived risks and benefits | PLOS ONE

Modafinil use in students 

In a study conducted on 15 students in the UK Russell Group University, the majority recorded using the medication in order to improve focus for studies.

While interviewing them, researchers gathered that students regarded university as an environment of heightened competitiveness that resulted in feelings of anxiety and stress. They initially used Modafinil to stay awake for a longer period and improve time efficiency.

The increase in productivity was interpreted as a prevention strategy to prevent exhaustion or burnout and increase focus especially when they needed to pull all-nighters and keep up their productivity for a longer time

While the majority recorded that they used Modafinil because it was legally available in the U.K unlike its restricted status in other countries, they further emphasized that it was better than other psychostimulants like Adderall, Ritalin, and coffee in enhancing productivity in the best possible manner.

While Modafinil’s ability to induce wakefulness had already been established, the loss of appetite with improved focus associated with its use was highlighted as the result. Most importantly the side effects associated with Modafinil were recorded to be significantly less than other psychostimulants

According to researchers of the European College of Neuropsychology, Modafinil can enhance cognition in individuals irrespective of their sleep deficits. It holds the well-deserved title of being the first pharmaceutical nootropic and can help people excel academically. That said, it is equally important to evaluate the ethical aspect of using the medication and keep in mind the harm that can arise from misusing or overusing it.

To be taken with a pinch of salt 

Despite its role as an emerging cognitive enhancer, it is important to understand the medication should not be overused or misused without consulting a medical professional for your overall safety. Keeping in mind neuroethical issues in cognitive management, the use of Modafinil should only be conducted in individuals with diagnosed sleep disorders for a short-term period under the supervision of a medical specialist. Further studies need to be conducted on the use of Modafinil in healthy individuals to obtain tangible results on its safety and efficiency.

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